Serra San Quirico is an Italian commune (comune) with 2850 inhabitants (as of December 31, 2015) in the province of Ancona in the Marches. The municipality is located about 44 kilometers west-southwest of Ancona on the Esino. Serra San Quirico is part of the Comunità montana dell'Esino Frasassi and borders the province of Macerata. Part of the territory is part of the Regional Natural Park of Gola della Rossa e di Frasassi.
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