Irsina is a municipality in the province of Matera in the Italian region of Basilicata. In Irsina 4960 inhabitants (31 December 2015). The village is located 48 km west of Matera. The neighboring municipalities are Genzano di Lucania (PZ), Grassano, Gravina in Puglia (BA), Grottole, Oppido Lucano (PZ), Tolve (PZ) and Tricarico.
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