Agnone is a comune (municipality) with a population of 5139 (December 31, 2015) in the province of Isernia in the Molise region. The village is located about 26 kilometers northeast of the provincial capital of Isernia and about 37 kilometers northwest of Campobasso. The community is located on the rivers and Verrino Sangro. It is immediately adjacent to the province of Chieti in the Abruzzo region.